Contact Problems in Cell Adhesion

by Cheng Zhu, Georgia Tech, Atlanta, United States,
Richard Skalak, Georgia Tech, Atlanta, United States,

Document Type: Proceeding Paper

Part of: Mechanics Computing in 1990's and Beyond


Adhesion of biological cells plays an important role in many physiological processes. For instance, the adhesion of killer T-lymphocyte to its target cell is an essential step in cytolysis, red blood cell adhesion leads to rouleau formation, and cell adhesion is a prime function of platelets. In the present work, we develop a model based on the contact mechanics of viscoelastic bodies and a thermodynamics analysis which allows derivation of the relations of the macroscopic quantities to the molecular properties.

Subject Headings: Contact mechanics | Adhesives | Thermal analysis | Biological processes | Thermodynamics | Bonding | Viscoelasticity

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