Properties of Intimal Layer and Adjacent Flow

by Ramesh N. Vaishnav, Prof. of Civ. Engrg.; The Catholic Univ. of America, Washington, D.C.,
Dali J. Patel, Medical Officer; The Section on Vascular Physiology, Lab. of Experimental Atherosclerosis, National Heart, Lung, and Blood Inst., The National Insts. of Health, Bethesda, Md.,
H. Bulent Atabek, Prof. of Mech. Engrg.; The Catholic Univ. of America, Washington, D.C.,

Serial Information: Journal of the Engineering Mechanics Division, 1978, Vol. 104, Issue 1, Pg. 67-77

Document Type: Journal Paper


The importance of the information on mechanical properties of the intimal layer and adjacent flow fields in studies of vessel wall permeability and pathogenesis of atherosclerosis is well recognized. The intimal layer was studied in excised segments of the blood vessel stretched to in vivo dimensions. The endothelium could withstand large normal stresses but was easily eroded by the shear stress resulting from a jet efflux. Relatively hard areas in the intimal layer distal to the intercostal orifices were found to relate to the increased collagen content and lower permeability to Evans blue dye. With the nonlinear theory of blood flow it was possible to compute accurately the pulsatile velocity profile and wall shear during a cardiac cycle in the descending thoracic aorta of a dog. The peak wall shear, under conditions of increased flow, approached the value 270 dyne/cm²; this value is close to the critical yield stress (400 dyne/cm²) for endothelial cells.

Subject Headings: Shear stress | Shear walls | Shear flow | Critical flow | Mechanical properties | Field tests | Wells (water) | Erosion

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